Chemical Carcinogens and DNA, Volume 1

7-methylguanine action activation adducts administration aflatoxin agents alkaloids alkylating agents alkylation amounts animals appears bacteriophage bases benzo(a)pyrene binding Biochem Biol biological Biophys bound Brookes Cancer Res carcinogen-DNA carcinogenesis carcinogens cells cellular Chapter Chem chemical chromatography compounds containing culture derivatives detected dose effects enzyme epoxide evidence example excision experiments extent factors Figure fluorescence formation formed guanine half-life hamster human hydrocarbons increased induced inhibition Interact involved isolated known Lawley less levels loss measurements mechanism metabolic activation metabolites method methyl mice microsomal Miller molecule mouse mutagenic mutation Nature London nucleic acids observed obtained occur polycyclic position possible preparations present protein pyrrolizidine radioactive rat liver reaction reactive relative repair reported sensitive showed shown similar species stability structure studies suggested synthesis Table techniques tion tissues toxicity treated treatment tumors types various vitro vivo