Chemical Carcinogens, Part 1

acid action alkylating agents animals appears aromatic amines assays associated bases benzo(a)pyrene binding Biochem bladder bladder cancer Cancer Inst Cancer Res carcinogenesis carcinogenic activity carcinoma cause cells Chem chemical compared compounds controls deaths demonstrated derivatives developed dihydrodiol epoxide disease dose effects enzymes epidemiological evidence example expected experiments exposure extensive factors finding formed further hamster hazard Health human hydrocarbons important incidence increased indicated induced industrial initiation injection Interact involved known laboratory less levels liver London lung major malignant mechanism metabolic metabolites methyl mice microsomal Miller mouse mouse skin mutagenic mutation Natl Nature observed occupational occur Pharmacol population positive possible potent present Proc reaction reactive region relatively reported risk sarcomas Scheme showed shown similar skin species structure studies suggested Table Toxicol tumors various vitro vivo workers yield